Afamelanotide (Topical)

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Afamelanotide (Topical)

What is Afamelanotide (Topical)
?

Afamelanotide (Topical) is a synthetic melanocyte-stimulating hormone analog that is indicated for the treatment of erythropoietic protoporphyria (EPP), a rare, genetic disorder that results in accumulation of protoporphyrin IX (PPIX) in the skin and other organs. PPIX accumulation causes photosensitivity and skin lesions. Afamelanotide (Topical) binds to and activates the melanocortin-1 receptor (MC1R), which stimulates the production of melanin. This increases the protection of the skin from the sun and reduces the development of new skin lesions.

Benefits of Afamelanotide (Topical)
and Its Uses.

Afamelanotide (topical) is a synthetic melanocortin receptor agonist that is used to treat erythropoietic protoporphyria.

Afamelanotide (topical) is a prescription medication that is used to treat erythropoietic protoporphyria, a rare disorder that affects the production of blood cells. People with erythropoietic protoporphyria have a defect in the enzyme that helps to break down the heme molecule in red blood cells. This defect results in the accumulation of heme in the skin, which can cause skin lesions, itching, and burning. Afamelanotide (topical) is a synthetic melanocortin receptor agonist that binds to the melanocortin receptors in the skin. This binding causes the production of melanin, the pigment that gives skin its color. The increased production of melanin helps to protect the skin from the harmful effects of

Side Effects and Dosage of Afamelanotide (Topical)

Afamelanotide (topical) is a synthetic melanocyte-stimulating hormone analog that is used to increase skin pigment (melanin) production in people with vitiligo, a skin condition that causes patches of the skin to lose their natural color.

Afamelanotide is available as an implant (Iprivask) and as a topical cream (Melanotan-II).

The most common side effects of afamelanotide (topical) are nausea, headache, and skin flushing.

Do not use afamelanotide if you are pregnant or breastfeeding.

Do not use afamelanotide if you have a history of skin cancer.

Use afamelanotide cautiously if you have a history of heart disease or stroke.

The recommended dosage of afamelanotide (topical) is 0.5 mg per day, applied to the affected areas of the skin.

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