Pegvaliase

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Pegvaliase

What is Pegvaliase
?

Pegvaliase is a medication that is used to treat phenylketonuria, which is a condition that results in the body being unable to break down a certain amino acid called phenylalanine. This amino acid can build up in the body and can cause a number of problems, including intellectual disability, seizures, and mental health problems. Pegvaliase helps to break down phenylalanine, which reduces the amount that builds up in the body.

Benefits of Pegvaliase
and Its Uses.

Pegvaliase is a new enzyme replacement therapy (ERT) for adults with phenylketonuria (PKU), a rare genetic disorder that causes high levels of the amino acid phenylalanine in the blood. Pegvaliase is a replacement for the defective enzyme phenylalanine hydroxylase, which is unable to convert phenylalanine to tyrosine. Tyrosine is an essential amino acid that is needed for the production of proteins and other important molecules in the body.

People with PKU cannot break down phenylalanine, so it builds up in the blood and can cause damage to the brain and other organs. Untreated, PKU can lead to intellectual disabilities, seizures, and other serious health problems. The goal of pegvaliase therapy is to reduce the amount of phenylalanine in the blood to safe levels.

Pegvaliase is a man-made enzyme that is identical to the one

Side Effects and Dosage of Pegvaliase

Pegvaliase is a prescription medication approved by the US Food and Drug Administration (FDA) to treat phenylketonuria (PKU), a rare genetic disorder that causes the body to unable to break down the amino acid phenylalanine. Pegvaliase is a form of the enzyme phenylalanine ammonia-lyase, which helps to break down phenylalanine in the body. Pegvaliase is available as a powder that is mixed with a liquid and given through a feeding tube.

The recommended dosage of pegvaliase depends on the weight of the person taking the medication. The starting dose is 0.5 mg/kg per day, which is divided into two doses and given 12 hours apart. The dose can be gradually increased to a maximum of 4 mg/kg per day, if needed.

Pegvaliase can cause side effects, including headache, dizziness, nausea, vomiting, diarrhea, constipation

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